Research Associate, Deborah Research Institute, 1995-96
NSERC Postdoctoral Fellow, Deborah Research Institute, Browns Mills, New Jersey 1993-95
Ph.D. University of Western Ontario, 1993
BSc. University of Western Ontario, 1987
BA. University of Western Ontario, 1984
The cellular response to muscle damage, including the regulation, expression and protection of stress/heat shock proteins/damage associated molecular patterns in striated muscle.
Cells respond to stressful conditions by rapidly synthesizing protective proteins known as Heat Shock Proteins (HSPs) or Stress Proteins (SPs). An elevated expression of HSPs has been shown to provide protection to cells and tissues during episodes of stress. HSPs are known to be involved in numerous processes and are likely to regulate important cell functions. I am currently examining the relationship between the content of HSPs and their ability to protect skeletal muscle from the damage associated with eccentric (lengthening) muscle contractions and the inflammatory response that follows. We use an ASI servo motor to induce skeletal muscle damage in the rat tibialis anterior muscle. We use this model in conjunction with other mammalian models (diabetes, hypertrophy, exercise, heat stress, cold stress, etc) to answer questions regarding the role that HSPs play in skeletal muscle protection.
Locke, M. & Celotti, C. (2014). The effect of heat stress on skeletal muscle contractile proteins. Cell Stress and Chaperones 19:519-527.
Holwerda AM, Locke M (2014). Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Applied Physiology, Nutrition and Metabolism 39(12):1380-7.
Lewis, E. J. H, Ramsook, A. H., Locke, M., & Amara, C. E. (2013). Mild eccentric exercise increases Hsp72 content in skeletal muscles from adult and late middle-aged rats. Cell Stress and Chaperones 18:667-673.
Di Battista, A. P. & Locke, M. (2013). Isolated hearts treated with skeletal muscle homogenates exhibit altered function. Cell Stress and Chaperones. 18:675-681.
Balan, M. & Locke, M. (2011). Acute exercise activates myocardial nuclear factor kappa B. Cell Stress and Chaperones16:105-111.
American College of Sports Medicine
Canadian Society for Exercise Physiology
International Cell Stress Society